Michal Nagiec, Ph.D.
Favorite movie: Dr. Strangelove or: How I Learned to Stop Worrying and Love the Bomb
Hometown: Warsaw, Poland
Non-science activity: Bike, hike, snowboard
Dream benchmate: Currently living the dream
One item from your bucket list: Backcountry riding in Alaska
Your scientific interests: Cancer cell biology, mechanisms of cell signaling and metabolism
Current research interests: Cancer cell biology, mechanisms of cell signaling and metabolism
Research
I am working to understand how signaling associated with epithelial-mesenchymal plasticity contributes to tumor aggressiveness and the rise of metastatic lesions. With a focus on identifying dependencies that occur in these cells, which might be exploited to treat disease.
Honors and Awards
2013-2015 Ruth L. Kirschstein National Research Service Award, NIGMS, NIH
2012 Dana-Farber Cancer Institute, Cancer Biology Training Award, NIH
2006-2008 Cell and Molecular Biology (CMB) Training Award, UNC/NIH
Selected Publications
Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability. Mutvei AP, Nagiec MJ, Hamann JC, Kim SG, Vincent CT, Blenis J.Nat Commun. 2020 Mar 17;11(1):1416.
Nagiec MJ, McCarter PC, Kelley JB, Dixit G, Elston TC, Dohlman HG. (2015) Signal inhibition by a dynamically regulated pool of monophosphorylated MAPK. Mol Biol Cell, 26(18):3359-71
Lien EC*, Nagiec MJ*, Dohlman HG. (2013) Proper protein glycosylation promotes MAPK signal fidelity. Biochemistry, 52(1):115-24 * denotes equal contribution.
Hao N*, Yildirim N*, Nagiec MJ*, Parnell SC, Errede B, Dohlman HG, Elston TC. (2012) Combined computational and experimental analysis reveals MAP kinase-mediated feedback phosphorylation as a mechanism for signaling specificity. Mol Biol Cell. * denotes equal contribution.
Nagiec MJ and Dohlman HG. (2012) Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress. PLoS Genetics, 8(1):e1002437.