2020

May

Publication: Structural Insights into the Activation of mTORC1 on the Lysosomal Surface. Trends in Biochemical Science

March

Publication: Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability. Nature Communications

2019

December

Christie Shea passes her Advancement to Candidacy Exam.

October

Publication: Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell

September

Publication: Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin. PNAS

June

Dr. Gina Lee wins the Tri-Institutional Breakout Award for Junior Investigators.

May

Dr. Ana P. Gomes gives a selected short talk in the Keystone Symposia: Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment.

March

Blenis Lab renews its “Mitogenic and Oncogenic Regulation of ERK/RSK Signaling” R01 grant from NIH (National Institute of Cancer)

2018

December

Blenis lab receives the Sanofi Innovation Award.

September

Joana Nunes successfully defends her PhD thesis.

August

Blenis lab holds its second annual retreat in Garrison, NY.

Publication: Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism? Frontiers in Cell and Developmental Biology

June

Publication: mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation. Molecular Cell

April

Kripa Shobana Ganesh passes her Advancement to Candidacy Exam.

March

Publication: Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization. Cancer Cell

January

Blenis Lab receives a Starr Cancer Consortium Grant.

 

2017

December

Publication: Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell 

Dr. Ana P. Gomes becomes one of the winners of the Bench to Bedside Initiative Tri-Institute Shark Thank. 

Dr. Ana P. Gomes is selected as a 2017 STAT Wunderkind. 

September

Blenis lab holds its first annual retreat at Orchard Hill Estate, Harriman, NY.

Publication: TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease. Cell 

Dr. Ana P. Gomes receives a Susan Komen Postdoctoral Fellowship. 

Dr. Ana P. Gomes receives a NIH K99/R01 Pathway to Independence Award from National Cancer Institute. 

August

Publication: Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular Cell

July

Publication: Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer. Developmental Cell

June

Tanya Schild receives a Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship (F31). 

Joana Nunes receives the Best Short Talk prize in the FEBS Advanced Lecture Course on Oncometabolism - From Conceptual Knowledge to Clinical Applications. Figueira da Foz, Portugal

May

Blenis Lab receives a Department of Defense grant from the Tuberous Sclerosis Complex Research Program. 

Dr. Ana P. Gomes becomes one of the finalists for the Regeneron Prize for Creative Innovation.

April

Dr. Bethany Schaffer receives a Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship (F32) 

Joana Nunes receives the best oral presentation prize in the 37th annual Vincent du Vigneaud Memorial Research Symposium at Weill Cornell Medicine, New York. 

January

Dr. Ana P. Gomes gives a selected short talk in the Keystone Symposia: Epigenetics and Human Disease: Progress from Mechanisms to Therapeutics

Dr. Gina Lee gives a selected short talk in the Keystone Symposia: PI3K Pathways in Immunology, Growth Disorders and Cancer.

 

2016

December

Blenis Lab receives a R03 grant from NIH (National Cancer Institute). 

August

Publication: mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress. Cancer Research

Gwen Buel successfully defends her PhD thesis.

July

Blenis Lab renews its “Signal Transduction to p70-S6 Kinase 1” R01 grant from NIH (National Institute of General Medical Sciences) 

March

Tanya Schild passes her Advancement to Candidacy Exam.

Vi Vien Low passes her Advancement to Candidacy Exam.

January

Publication: Seeing mTORC1 specificity. Science 

 

2015

December

Dr. Anders Mutvei receives a fellowship from Vetenskapsrådet (Swedish Research Counsel) 

October

Blenis Lab receives funding from Highline Therapeutics as part of the Highline Translational Alliance Program. 

September

Dr. Gina Lee gives an invited talk at the International Tuberous Sclerosis Complex Research Conference in the UK.

August

Publication: A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways. Current Opinion in Biotechnology

July

Tanya Schild is selected for the Institutional predoctoral Ruth L. Kirschstein National Research Service Award Individual, T32 training grant 

May

Publication: ERK reinforces actin polymerization to power persistent edge protrusion during motility. Science Signaling 

January

Publication: Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells. PNAS

 

2014

October

Publication: The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the
eIF4B-Dependent Control of c-Myc Translation. Current Biology

June

Blenis Lab moves to Weill Cornell Medicine in New York from Harvard University.

April

Blenis Lab renews its “Mitogenic and Oncogenic Regulation of ERK/RSK Signaling” R01 grant from NIH (National Cancer Institute) 

March

Publication: Rapamycin: one drug, many effects. Cell Metabolism. 

February

Publication: Akt-ivation of RNA splicing. Molecular Cell

Dr. Gina Lee receives a postdoctoral fellowship from The Lymphangioleiomyomatosis (LAM) Foundation

January

Blenis Lab receives a new R01 to study lymphangioleiomyomatosis (LAM) from NIH (National Heart, Lung, and Blood Institute). 

 

2013

December

Dr. Gina Lee receives a postdoctoral fellowship from Tuberous Sclerosis Alliance 

September

Dr. Michal Nagiec receives a Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship (F32)

Publication: Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. PNAS

June

Publication: AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Science Signaling

Publication: Nutrient regulation of the mTOR complex 1 signaling pathway. Molecules and Cells

May

Publication: The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell 

Publication: mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis. Cell Metabolism

January

Publication: Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Molecular Cell

 

2012

December

Dr. Jeannie Li receives a postdoctoral fellowship from Tuberous Sclerosis Alliance

Publication: Hippo-YAP and mTOR pathways collaborate to regulate organ size. Nature Cell Biology

September

Dr. Michelle Mendoza receives a NIH K01 Mentored Research Scientist Career Development Award from the National Cancer Institute. 

Dr. Gina Lee receives a postdoctoral fellowship from the Next Generation Research Program, Korean Government

July

Dr. Michal Nagiec is selected for the T32 Dana Farber Tumor Cell Biology Postdoctoral Training grant.

June

Dr. Long He receives a WCI postdoctoral fellowship from Korean Research Institute of Bioscience and Biotechnology. 

April

Publication: Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling. Journal of Biological Chemistry